Correction: A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt
نویسندگان
چکیده
The pattern of epidemic meningococcal disease in the African meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was established at five centres within the meningitis belt. Antibody concentrations were then measured in 3930 individuals stratified by age and residence from six countries. Seroprevalence by age was used in a catalytic model to determine the force of infection. Meningococcal serogroup A IgG antibody concentrations were high in each country but showed heterogeneity across the meningitis belt. The geometric mean concentration (GMC) was highest in Ghana (9.09 μg/mL [95% CI 8.29, 9.97]) and lowest in Ethiopia (1.43 μg/mL [95% CI 1.31, 1.57]) on the margins of the belt. The force of infection was lowest in Ethiopia (λ = 0.028). Variables associated with a concentration above the putative protective level of 2 μg/mL were age, urban residence and a history of recent vaccination with a meningococcal vaccine. Prior to vaccination with the serogroup A meningococcal conjugate vaccine, meningococcal serogroup A IgG antibody concentrations were high across the African meningitis belt and yet the region remained susceptible to epidemics.
منابع مشابه
Incidence, Carriage and Case-Carrier Ratios for Meningococcal Meningitis in the African Meningitis Belt: A Systematic Review and Meta-Analysis
BACKGROUND To facilitate the interpretation of meningococcal meningitis epidemiology in the "African meningitis belt", we aimed at obtaining serogroup-specific pooled estimates of incidence, carriage and case-carrier ratios for meningococcal meningitis in the African meningitis belt and describe their variations across the endemic, hyperendemic and epidemic context. METHODS We conducted a sys...
متن کاملContinuing risk of meningitis due to Neisseria meningitidis serogroup C in Africa: revised recommendations from a WHO expert consultation.
Context Although cases of Neisseria meningitidis serogroup A (NmA) in the African meningitis belt have declined dramatically following the extensive roll-out of MenAfriVac, a monovalent serogroup A conjugate vaccine, outbreaks due to other meningococcal serogroups have continued.1 More than 25 000 suspected cases of meningitis across the meningitis belt have been reported in each of the past 3 ...
متن کاملMeningococcal carriage in the African meningitis belt
A meningococcal serogroup A polysaccharide/tetanus toxoid conjugate vaccine (PsA-TT) (MenAfriVac(™) ) is being deployed in countries of the African meningitis belt. Experience with other polysaccharide/protein conjugate vaccines has shown that an important part of their success has been their ability to prevent the acquisition of pharyngeal carriage and hence to stop transmission and induce her...
متن کاملMeningococcal carriage within households in the African meningitis belt: A longitudinal pilot study
OBJECTIVES Carriers of Neisseria meningitidis are a key source of transmission. In the African meningitis belt, where risk of meningococcal disease is highest, a greater understanding of meningococcal carriage dynamics is needed. METHODS We randomly selected an age-stratified sample of 400 residents from 116 households in Bamako, Mali, and collected pharyngeal swabs in May 2010. A month later...
متن کاملEditorial: Meningococcal disease.
Meningococcal disease causes at least 500,000 cases and 50,000 deaths worldwide each year. Epidemics of meningococcal meningitis occur in many parts of the world. Serogroup A is associated with explosive epidemics with attack rates up to 500 per 100,000. An epidemic of serogroup A in the African ‘meningitis belt’, which began in 1996, has resulted in at least 300,000 cases to date and many thou...
متن کامل